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SIS17

SIS17 是一种有效的选择性 HDAC 11 抑制剂，IC50 值为 0.83 μM。它可抑制 HDAC11 底物丝氨酸羟甲基转移酶 2 的去肉豆蔻酰化。

CAS号

2374313-54-7

分子式

C21H38N2OS

主要靶点

HDAC

仅限科研使用

Cat No : CM04418

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Synonyms

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  • CAS No.: 2374313-54-7

    SIS17
    CAS#: 2374313-54-7

产品信息

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

CAS号 2374313-54-7
分子式 C21H38N2OS
主要靶点 HDAC
主要通路 表观遗传|DNA损伤和修复
分子量 366.6
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

HDAC11:0.83 μM (IC50)

体外活性

SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

溶解度

DMSO:125 mg/mL (340.97 mM)

参考文献

1.Son S I , Cao J , Zhu C L , et al. Activity-Guided Design of HDAC11-Specific Inhibitors[J]. ACS Chemical Biology, 2019, 14(7):1393-1397.

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