验证数据展示
经过测试的应用
| Positive WB detected in | mouse kidney tissue, L02 cells, mouse heart tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:3000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| WB | See 6 publications below |
产品信息
20676-1-AP targets SLC16A2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier family 16, member 2 (monocarboxylic acid transporter 8) |
| 别名 | AHDS, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, Monocarboxylate transporter 7, Monocarboxylate transporter 8, MRX22, SLC16A2, XPCT |
| 计算分子量 | 60 kDa |
| 观测分子量 | 50-65 kDa |
| GenBank蛋白编号 | NM_006517 |
| 基因名称 | SLC16A2 |
| Gene ID (NCBI) | 6567 |
| RRID | AB_10695188 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P36021 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SLC16A2, also named as MCT8 and XPCT, belongs to the major facilitator superfamily and Monocarboxylate porter (TC 2.A.1.13) family. SLC16A2 is a very active and specific thyroid hormone transporter. SLC16A2 stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. It does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency). This antibody is specific to SLC16A2.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for SLC16A2 antibody 20676-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Int J Mol Sci Smoothelin-Like Protein 1 Regulates the Thyroid Hormone-Induced Homeostasis and Remodeling of C2C12 Cells via the Modulation of Myosin Phosphatase. | ||
Front Pharmacol Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1. | ||
PLoS One Tissue-Specific Expression of Monocarboxylate Transporters during Fasting in Mice. | ||
Pharm Res Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier. | ||
Toxicology MiR-24-3p/Dio3 axis is essential for BDE47 to induce local thyroid hormone disorder and neurotoxicity | ||
Toxicology BDE209-promoted Dio2 degradation in H4 glioma cells through the autophagy pathway, resulting in hypothyroidism and leading to neurotoxicity |
