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SM-324405

SM-324405 是TLR7的激动剂，EC50 为 50 nM，对人和大鼠 TLR7 的 pEC50值分别为 7.3 和 6.6，可用于过敏性疾病的免疫治疗研究。

CAS号

677773-91-0

分子式

C19H23N5O4

主要靶点

TLR

仅限科研使用

Cat No : CM06674

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Synonyms

SM 324405

验证数据展示

  • CAS No.: 677773-91-0

    SM-324405
    CAS#: 677773-91-0

产品信息

SM-324405 is an agonist of TLR7.

CAS号 677773-91-0
分子式 C19H23N5O4
主要靶点 TLR
主要通路 免疫与炎症
分子量 385.42
纯度 96.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 SM 324405

体内活性

The TLR7 agonist with antedrug characteristics 9e (SM-324405) is a novel candidate for immunotherapy of allergic diseases[1].

溶解度

DMSO:9 mg/mL (23.35 mM)

参考文献

1.Kurimoto A, Hashimoto K, Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72.
2.Biological characterization of a novel class of toll‐like receptor 7 agonists designed to have reduced systemic activity[J]. British Journal of Pharmacology, 2012, 166(2).

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