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SMG6 Monoclonal antibody, PBS Only

SMG6 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1D2G2

Cat no : 68109-1-PBS

Print datasheet

Synonyms

C17orf31, EST1 like protein A, EST1A, Ever shorter telomeres 1A, hSmg5/7a, KIAA0732, SMG 6, Smg 6 homolog, SMG6, Telomerase subunit EST1A

验证数据展示

  • WB analysis using 68109-1-Ig (same clone as 68109-1-PBS)

    WB analysis using 68109-1-Ig (same clone as 68109-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68109-1-Ig (SMG6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with Lamin B1 Monoclonal antibody (66095-1-Ig) as loading control. This data was developed using the same antibody clone with 68109-1-PBS in a different storage buffer formulation.

  • WB analysis of RAW 264.7 using 68109-1-Ig (same clone as 68109-1-PBS)

    WB analysis of RAW 264.7 using 68109-1-Ig (same clone as 68109-1-PBS)

    RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 68109-1-Ig (SMG6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68109-1-PBS in a different storage buffer formulation.

产品信息

68109-1-PBS targets SMG6 in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, mouse
Immunogen SMG6 fusion protein Ag30182 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms C17orf31, EST1 like protein A, EST1A, Ever shorter telomeres 1A, hSmg5/7a, KIAA0732, SMG 6, Smg 6 homolog, SMG6, Telomerase subunit EST1A
Calculated Molecular Weight 160 kDa
Observed Molecular Weight160 kDa
GenBank Accession NumberNM_017575
Gene Symbol SMG6
Gene ID (NCBI) 23293
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ86US8
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SMG6, also known as C17orf31, EST1A, and hEST1A, is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PMID: 19179534). It promotes in vitro the ability of TERT to elongate telomeres (PMID: 12676087, 12699629). SMG6 also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD (PMID: 19060897, 20930030). Alternate splicing results in multiple transcript variants (PMID: 12699629, 14636577).