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SNX12 Monoclonal antibody, PBS Only

SNX12 Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Mouse, Rat

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C6C8

Cat No : 68260-1-PBS

Print datasheet

Synonyms

SNX12, sorting nexin 12

验证数据展示

  • WB analysis using 68260-1-Ig (same clone as 68260-1-PBS)

    WB analysis using 68260-1-Ig (same clone as 68260-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68260-1-Ig (SNX12 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 68260-1-PBS in a different storage buffer formulation.

产品信息

68260-1-PBS targets SNX12 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human, Mouse, Rat
Immunogen SNX12 fusion protein Ag3014 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name sorting nexin 12
Synonyms SNX12, sorting nexin 12
Calculated Molecular Weight 172 aa, 20 kDa
Observed Molecular Weight18 kDa
GenBank Accession NumberBC020559
Gene Symbol SNX12
Gene ID (NCBI) 29934
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9UMY4
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

SNXs (sorting nexins) are a diverse group of cytoplasmic and membrane-associated proteins that are classified by the presence of a phospholipid-binding motif-the PX domain (PMID:12461558). SNXs are involved in endocytosis and protein trafficking. SNX12 (Sorting nexin 12) is localized in early endosomes and SNX12 overexpression specifically prevents the degradative pathway from early to late endosomes/lysosomes (PMID: 22719997). SNX12 may participate in Alzheimer's disease (AD) pathology by regulating the endocytosis of BACE1 and affecting β-processing of APP (PMID: 22709416).