SREBF1 Recombinant antibody, PBS Only
SREBF1 Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1P4
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy SREBF1 Ready-To-Use IHC Kit. SREBF1 primary antibody included.
产品信息
82684-3-PBS targets SREBF1 in WB, Indirect ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | SREBF1 fusion protein Ag5219 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | sterol regulatory element binding transcription factor 1 |
Synonyms | bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1 |
Calculated Molecular Weight | 1177 aa, 125 kDa |
Observed Molecular Weight | 125 kDa |
GenBank Accession Number | BC063281 |
Gene Symbol | SREBF1 |
Gene ID (NCBI) | 6720 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P36956 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
背景介绍
SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids. [PMID: 21698267].