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验证数据展示

  • WB analysis of LNCaP using 67349-1-Ig (same clone as 67349-1-PBS)

    WB analysis of LNCaP using 67349-1-Ig (same clone as 67349-1-PBS)

    LNCaP cells were subjected to SDS PAGE followed by western blot with 67349-1-Ig (SRY antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67349-1-PBS in a different storage buffer formulation.

  • WB analysis using 67349-1-Ig (same clone as 67349-1-PBS)

    WB analysis using 67349-1-Ig (same clone as 67349-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67349-1-Ig (SRY antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. SRY negative cell line HeLa cell line was served as negative control. This data was developed using the same antibody clone with 67349-1-PBS in a different storage buffer formulation.

SRY Monoclonal antibody, PBS Only

SRY Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67349-1-PBS

产品说明书

CloneNo. 2E9A4

宿主/亚型

Mouse / IgG1

种属反应性

human, rat

应用

WB, Indirect ELISA

别名

Testis-determining factor, Sex-determining region Y protein, sex determining region Y, 2E9A4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67349-1-PBS targets SRY in WB, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原 SRY fusion protein Ag12610 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 sex determining region Y
别名 Testis-determining factor, Sex-determining region Y protein, sex determining region Y, 2E9A4
计算分子量 204 aa, 24 kDa
观测分子量 25-30 kDa
GenBank蛋白编号BC074924
基因名称 SRY
Gene ID (NCBI) 6736
RRIDAB_2882607
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ05066
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females.