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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • IHC staining of human gliomas using 12027-1-AP (same clone as 12027-1-PBS)

    IHC staining of human gliomas using 12027-1-AP (same clone as 12027-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 12027-1-AP (STMN4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12027-1-PBS in a different storage buffer formulation.

  • WB analysis of human brain using 12027-1-AP (same clone as 12027-1-PBS)

    WB analysis of human brain using 12027-1-AP (same clone as 12027-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 12027-1-AP (STMN4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12027-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 12027-1-AP (same clone as 12027-1-PBS)

    IP experiment of mouse brain using 12027-1-AP (same clone as 12027-1-PBS)

    IP result of anti-STMN4 (IP:12027-1-AP, 3ug; Detection:12027-1-AP 1:1000) with mouse brain tissue lysate 6000ug. This data was developed using the same antibody clone with 12027-1-PBS in a different storage buffer formulation.

STMN4 Polyclonal antibody, PBS Only

STMN4 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 12027-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

12027-1-PBS targets STMN4 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 STMN4 fusion protein Ag2657 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 stathmin-like 4
别名
计算分子量 216 aa, 25 kDa
观测分子量 22-30 kDa
GenBank蛋白编号BC011520
基因名称 STMN4
Gene ID (NCBI) 81551
RRIDAB_2197401
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H169
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases. STMN4 has 4 isoforms with MW 25, 23, 22 and 19 kDa (refer to UniProt). Another 30 kDa isoform can be found by NCBI Protein Blast. (https://www.ncbi.nlm.nih.gov/protein/XP_005273709)