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  • Featured Product
  • KD/KO Validated

SURVIVIN Monoclonal antibody, PBS Only

SURVIVIN Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3B9H7

Cat No : 66495-1-PBS

Print datasheet

Synonyms

API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN

验证数据展示

  • WB analysis using 66495-1-Ig (same clone as 66495-1-PBS)

    WB analysis using 66495-1-Ig (same clone as 66495-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66495-1-Ig (SURVIVIN antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy SURVIVIN Ready-To-Use IHC Kit. SURVIVIN primary antibody included.

产品信息

66495-1-PBS targets SURVIVIN in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen SURVIVIN fusion protein Ag20958 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name baculoviral IAP repeat-containing 5
Synonyms API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN
Calculated Molecular Weight 16 kDa
Observed Molecular Weight 18 kDa
GenBank Accession NumberBC008718
Gene Symbol BIRC5
Gene ID (NCBI) 332
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO15392
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.