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验证数据展示

  • WB analysis using 66495-1-Ig (same clone as 66495-1-PBS)

    WB analysis using 66495-1-Ig (same clone as 66495-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66495-1-Ig (SURVIVIN antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66495-1-Ig (SURVIVIN antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human skin cancer using 66495-1-Ig (same clone as 66495-1-PBS)

    IHC staining of human skin cancer using 66495-1-Ig (same clone as 66495-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 66495-1-Ig (SURVIVIN antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66495-1-Ig (SURVIVIN antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    IHC staining of human tonsillitis using 66495-1-Ig (same clone as 66495-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66495-1-Ig (SURVIVIN antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66495-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • Featured Product
  • KD/KO验证

SURVIVIN Monoclonal antibody, PBS Only

SURVIVIN Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66495-1-PBS

产品说明书

CloneNo. 3B9H7

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

BIRC5, IAP4, EPR 1, BIRC 5, Baculoviral IAP repeat-containing protein 5

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy SURVIVIN Ready-To-Use IHC Kit. SURVIVIN primary antibody included.

产品信息

66495-1-PBS targets SURVIVIN in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 SURVIVIN fusion protein Ag20958 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 baculoviral IAP repeat-containing 5
别名 BIRC5, IAP4, EPR 1, BIRC 5, Baculoviral IAP repeat-containing protein 5
计算分子量 16 kDa
观测分子量 18 kDa
GenBank蛋白编号BC008718
基因名称 Survivin
Gene ID (NCBI) 332
RRIDAB_2881860
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO15392
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.