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Serotonin transporter Recombinant antibody, PBS Only

Serotonin transporter Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242252B9

Cat no : 84844-3-PBS

Print datasheet

Synonyms

SLC6A4, HTT, hSERT, 5HTT, 5 HTTLPR

验证数据展示

  • WB analysis using 84844-3-RR (same clone as 84844-3-PBS)

    WB analysis using 84844-3-RR (same clone as 84844-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84844-3-RR (Serotonin transporter antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84844-3-PBS in a different storage buffer formulation.

产品信息

84844-3-PBS targets Serotonin transporter in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms SLC6A4, HTT, hSERT, 5HTT, 5 HTTLPR
Calculated Molecular Weight 70 kDa
Observed Molecular Weight70 kDa
GenBank Accession NumberNM_001045
Gene Symbol Serotonin transporter
Gene ID (NCBI) 6532
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP31645
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Serotonin transporter (SERT; SLC6A4) belongs to the sodium- and chloride-dependent monoamine transporter family. SERT is a membrane transporter that terminates the neurotransmission of serotonin, a monoaminergic neurotransmitter, through its reuptake. The SERT uptake mechanism acquires energy for active transport via ATP hydrolysis or movement against electrochemical gradients. As an oligomeric N-glycan, SERT contains disulfide bonds between cysteine residues on the second extracellular domain. Post-translational modifications regulate the uptake kinetics and membrane trafficking of SERT, partly by regulating the proper folding and assembly of SERT in a host-dependent manner (PMID: 30394319).