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Smurf1-IN-A01

Smurf1-IN-A01 (A01) 是泛素连接酶 Smad 泛素化调节因子-1(Smurf1)抑制剂，其kd=3.664 nM。它能够抑制 Smurf1 介导的 Smad1/5 降解，并提高 BMP-2 的反应性。

CAS号

1007647-73-5

分子式

C22H20ClF3N4O3S

主要靶点

Others

仅限科研使用

Cat No : CM03848

Print datasheet

Synonyms

A01

验证数据展示

  • CAS No.: 1007647-73-5

    Smurf1-IN-A01
    CAS#: 1007647-73-5

产品信息

Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.

CAS号 1007647-73-5
分子式 C22H20ClF3N4O3S
主要靶点 Others
主要通路 其他
分子量 512.932
纯度 99.54%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 A01

靶点活性

Smurf1:(kd)3.664 nM

溶解度

DMSO:62.5 mg/mL (121.85 mM),Sonification is recommended.

参考文献

1.Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.

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