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Monensin sodium salt

Monensin sodium salt (Monensin A sodium salt) 是由肉桂链霉菌 分泌的抗生素。它是一种介导Na+/H+交换的离子载体。它引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。

CAS号

22373-78-0

分子式

C36H61NaO11

主要靶点

Antibiotic|Antibacterial|Sodium Channel

仅限科研使用

Cat No : CM00375

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Synonyms

莫能菌素钠盐|Sodium Monensin|Monensin A sodium salt

验证数据展示

  • CAS No.: 22373-78-0

    Monensin sodium salt
    CAS#: 22373-78-0

产品信息

Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt causes a marked enlargement of the MVBs and regulates exosome secretion

CAS号 22373-78-0
分子式 C36H61NaO11
主要靶点 Antibiotic|Antibacterial|Sodium Channel
主要通路 微生物学|离子通道
分子量 692.85
纯度 98.74%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 莫能菌素钠盐|Sodium Monensin|Monensin A sodium salt

体内活性

LD50: Mice 335 mg/kg (i.g.) [4]; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.). [5]

体外活性

Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3]

溶解度

Ethanol:69.3 mg/mL (100 mM)

参考文献

1.Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546.
2.Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246.
3.Huczynski A, et al. Bioorg Med Chem Lett, 2008, 18(8), 2585-2589.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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