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Ponalrestat

Ponalrestat 是一种口服有效的，选择性的和非竞争性的醛糖还原酶抑制剂，对 ALR2选择性选择性较高，Ki 为 7.7 nM， 对 ALR1 的选择性较弱，Ki 为 60 μM。Ponalrestat 抑制葡萄糖向山梨糖醇的转化。

CAS号

72702-95-5

分子式

C17H12BrFN2O3

主要靶点

Reductase

仅限科研使用

Cat No : CM02595

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Synonyms

验证数据展示

  • CAS No.: 72702-95-5

    Ponalrestat
    CAS#: 72702-95-5

产品信息

Ponalrestat is an aldose reductase inhibitor.

CAS号 72702-95-5
分子式 C17H12BrFN2O3
主要靶点 Reductase
主要通路 内分泌与激素|代谢
分子量 391.19
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

ALR2:7.7 nM (Ki)|ALR1:60 μM (Ki)

溶解度

DMSO:45 mg/mL (115.03 mM)

参考文献

1.Pekiner C, McLean WG. Br J Pharmacol. 1990 Dec;101(4):978-80.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2