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Thalidomide 4-fluoride

Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

CAS号

835616-60-9

分子式

C13H9FN2O4

主要靶点

IRAK|Ligand for E3 Ligase

仅限科研使用

Cat No : CM01674

Print datasheet

Synonyms

2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮|E3 ligase Ligand 4

验证数据展示

  • CAS No.: 835616-60-9

    Thalidomide 4-fluoride
    CAS#: 835616-60-9

产品信息

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

CAS号 835616-60-9
分子式 C13H9FN2O4
主要靶点 IRAK|Ligand for E3 Ligase
主要通路 NF-κB信号通路|免疫与炎症|PROTAC
分子量 276.22
纯度 99.12%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮|E3 ligase Ligand 4

溶解度

DMSO:199 mg/mL (720.44 mM)

参考文献

1.Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2