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TC13172

TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2±0.6 nM for HT-29 cells.

CAS号

2093393-05-4

分子式

C17H16N4O5S

主要靶点

MLKL

仅限科研使用

Cat No : CM05182

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Synonyms

验证数据展示

  • CAS No.: 2093393-05-4

    TC13172
    CAS#: 2093393-05-4

  • TC13172<br/>CAS#: 2093393-05-4

    TC13172
    CAS#: 2093393-05-4

产品信息

Mixed lineage kinase domain-like protein (MLKL) is a necroptosis executor that mediates ion influx and causes cell structure disruption. TC13172 is a MLKL inhibitor that shows anti-necroptosis potency with an EC50 value of 2 ? 0.6 nM in TNF-a/Smac mimetic/Z-VAD-fmk-treated HT-29 cells. In HT-29 cells pre-incubated with 100 nM TC13172 for 2 hours and then treated with another MLKL inhibitor with a propyne group at the dose of 1 μM for additional 2 hours, TC13172 efficiently outcompeted the other inhibitor in binding to MLKL. Treatment of HT-29 cells with 100 nM TC13172 for 8 hours blocked the oligomerization and translocation of MLKL from the cytoplasm to the cell membrane but did not disrupt the phosphorylation of MLKL.

CAS号 2093393-05-4
分子式 C17H16N4O5S
主要靶点 MLKL
主要通路 Others
分子量 388.3977
MDL NO
Pubchem ID 134691750.0
纯度 98.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名

靶点

TargetActivity
MLKLEC50=2±0.6nM

溶解度

DMSO25 mg/mL
WaterInsoluble

参考文献

1Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein.

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