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TDZD-8

CAS号

327036-89-5

分子式

C10H10N2O2S

主要靶点

GSK-3

仅限科研使用

Cat No : CM04335

Print datasheet

Synonyms

Inhibitor|NP01139|NP-01139|NP 01139|TDZD 8|TDZD8|TDZD-8|inhibit|Glycogen synthase kinase 3|Glycogen synthase kinase-3|GSK-3β Inhibitor I|GSK-3β|GSK-3b Inhibitor I|GSK-3beta Inhibitor I|GSK3|GSK-3

验证数据展示

  • CAS No.: 327036-89-5

    TDZD-8
    CAS#: 327036-89-5

产品信息

CAS号 327036-89-5
分子式 C10H10N2O2S
主要靶点 GSK-3
主要通路 干细胞|PI3K/Akt/mTOR 信号通路
分子量 222.26
纯度 99.48%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|NP01139|NP-01139|NP 01139|TDZD 8|TDZD8|TDZD-8|inhibit|Glycogen synthase kinase 3|Glycogen synthase kinase-3|GSK-3β Inhibitor I|GSK-3β|GSK-3b Inhibitor I|GSK-3beta Inhibitor I|GSK3|GSK-3

靶点活性

GSK-3β:2 μM

体外活性

TDZD-8 作为 ATP 或 GS-1 结合的非竞争抑制剂发挥作用。TDZD-8 在激酶实验中不抑制 PKA、PKC、Cdk-1/cyclin B 或 CK-II。[1] TDZD-8 特异性诱导原发性白血病样本的细胞死亡，并清除白血病干细胞和祖细胞。TDZD-8 处理诱导氧化应激，通过极其快速的细胞死亡动力学引起的细胞死亡，表现为细胞膜完整性的丧失。TDZD-8 在原发性AML样本中抑制 PKC 和 FLT3。[2]

溶解度

H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:70 mg/mL (314.95 mM);Ethanol:44.5 mg/mL (200.22 mM)

参考文献

1.Martinez A, et al. J Med Chem, 2002, 45(6), 1292-1299.
2.Guzman ML, et al. Blood, 2007, 110(13), 4436-4444.

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The dilution calculator equation

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