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  • Featured Product
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TEAD2 Polyclonal antibody, PBS Only

TEAD2 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 21159-1-PBS

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Synonyms

验证数据展示

  • WB analysis of mouse colon using 21159-1-AP (same clone as 21159-1-PBS)

    WB analysis of mouse colon using 21159-1-AP (same clone as 21159-1-PBS)

    mouse colon tissue were subjected to SDS PAGE followed by western blot with 21159-1-AP (TEAD2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21159-1-PBS in a different storage buffer formulation.

产品信息

21159-1-PBS targets TEAD2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen TEAD2 fusion protein Ag14074 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name TEA domain family member 2
Synonyms
Calculated Molecular Weight 447 aa, 49 kDa
Observed Molecular Weight 55-65 kDa
GenBank Accession NumberBC051301
Gene Symbol TEAD2
Gene ID (NCBI) 8463
RRIDAB_2861186
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ15562
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TEAD2 belongs to a protein family that shares the TEA/ATTS domain. It acts as a transcriptional factor by cooperatively binding to the GT-IIC and Sph(I 1 II) enhansons in the simian virus 40 (SV40) enhancer. Also, it can modulate SV40 late transcription together with a large T antigen. The transcriptional activity of TEAD2 required several regions of the proteins, TBP-associated factors, and limiting transcriptional intermediary factors. TEAD2 also performs an essential role in the Hippo signaling pathway. TEAD2 regulates gene expression of YAP1 and WWTR1/TAZ, thus mediating cell proliferation, migration, and epithelial-mesenchymal transition induction. TEAD2 is strongly expressed in the human ovarian carcinoma cell line.