验证数据展示
发表文章中的应用
| WB | See 2 publications below |
产品信息
18994-1-AP targets TERT in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | telomerase reverse transcriptase |
| 别名 | EST2, hEST2, hTERT, TCS1, Telomerase catalytic subunit, TERT, TP2, TRT |
| 计算分子量 | 127 kDa |
| GenBank蛋白编号 | NM_198255 |
| 基因名称 | TERT |
| Gene ID (NCBI) | 7015 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O14746 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TERT,also named as EST2, TCS1 and TRT, belongs to the reverse transcriptase family and Telomerase subfamily. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis. TERT elongates telomeres by adding simple sequence repeats to chromosome ends. TERT can modulate Wnt signaling and plays important roles in aging and antiapoptosis. Mutation of TERT are associated with susceptibilty to aplastic anemia (AA), coronary artery disease (CAD), dyskeratosis congenita autosomal dominant (ADDKC) and idiopathic pulmonary fibrosis. Catalog#18994-1-AP is rabbit polyclonal antibody that can recognize all the 3 TERT isoforms.
发表文章
| Species | Application | Title |
|---|---|---|
Cancer Med Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression. | ||
Hepat Mon Targeting Human Telomerase Reverse Transcriptase by a Simple siRNA Expression Cassette in HepG2 Cells. |