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Species Reactivity
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Species Reactivity
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验证数据展示

  • IHC staining of mouse testis using 18351-1-AP (same clone as 18351-1-PBS)

    IHC staining of mouse testis using 18351-1-AP (same clone as 18351-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 18351-1-AP (TEX14 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18351-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 18351-1-AP (same clone as 18351-1-PBS)

    IHC staining of mouse testis using 18351-1-AP (same clone as 18351-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 18351-1-AP (TEX14 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18351-1-PBS in a different storage buffer formulation.

TEX14 Polyclonal antibody, PBS Only

TEX14 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 18351-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

18351-1-PBS targets TEX14 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 TEX14 fusion protein Ag13177 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 testis expressed 14
别名
计算分子量957aa,107 kDa; 1497aa,168 kDa
观测分子量 180-200 kDa, 106 kDa
GenBank蛋白编号BC040526
基因名称 TEX14
Gene ID (NCBI) 56155
RRIDAB_10641992
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8IWB6
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tex14 is required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Tex14 acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges.Tex14 also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Tex14 has several variant isoforms with the MW from about 100 kDa to 168 kDa.