验证数据展示
产品信息
CL488-67076 targets TFAP2A,AP-2 in applications and shows reactivity with Human, mouse, rat samples.
| 经测试应用 | Application Description |
| 经测试反应性 | Human, mouse, rat |
| 免疫原 | TFAP2A,AP-2 fusion protein Ag4112 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| 别名 | TFAP2A, AP-2, AP2, AP 2alpha, AP 2 |
| 计算分子量 | 431 aa, 47 kDa |
| 观测分子量 | 47 kDa |
| GenBank蛋白编号 | BC017754 |
| 基因名称 | TFAP2A/AP-2 |
| Gene ID (NCBI) | 7020 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P05549 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The activator protein-2 (AP-2) family of transcription factors comprises five 52-kDa isoforms (AP-2α, AP-2β, AP-2γ, AP-2δ, and AP-2ε), which share a common structure: a proline/glutamine-rich transactivation domain in the N-terminal region and a helix-span-helix domain in the C-terminal region, which mediates dimerization and site-specific DNA binding. Depending on the cellular context, the AP-2 transcription factors are individually associated either with cell differentiation and development or with cancer progression/regression. [PMID:21966377] TFAP2A (AP-2-alpha) is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation [PMID:11694877]