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TGFBR3 Polyclonal antibody

TGFBR3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28992-1-AP

Print datasheet

Synonyms

TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN

验证数据展示

  • WB analysis using 28992-1-AP

    WB analysis using 28992-1-AP

    Human placenta tissue was subjected to SDS PAGE followed by western blot with 28992-1-AP (TGFBR3 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inhuman placenta tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

28992-1-AP targets TGFBR3 in WB, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen TGFBR3 fusion protein Ag29397 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name transforming growth factor, beta receptor III
Synonyms TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN
Observed Molecular Weight130 kDa
GenBank Accession NumberBC136295
Gene Symbol TGFBR3
Gene ID (NCBI) 7049
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ03167
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106).

实验方案

Product Specific Protocols
WB protocol for TGFBR3 antibody 28992-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols