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TGFBR3 Polyclonal antibody

TGFBR3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28992-1-AP

Print datasheet

Synonyms

TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN

验证数据展示

  • WB analysis using 28992-1-AP

    WB analysis using 28992-1-AP

    Human placenta tissue was subjected to SDS PAGE followed by western blot with 28992-1-AP (TGFBR3 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inhuman placenta tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

28992-1-AP targets TGFBR3 in WB, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen TGFBR3 fusion protein Ag29397 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name transforming growth factor, beta receptor III
Synonyms TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN
Observed Molecular Weight130 kDa
GenBank Accession NumberBC136295
Gene Symbol TGFBR3
Gene ID (NCBI) 7049
RRIDAB_3086094
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ03167
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106).

实验方案

Product Specific Protocols
WB protocol for TGFBR3 antibody 28992-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols