CoraLite® Plus 405 Anti-Mouse TIGIT Rabbit Recombinant Antibody

TIGIT Uni-rAbTM Recombinant Antibody for FC
Cat No. CL405-98026

产品说明书

CloneNo. 240242G1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

Vstm3, 240242G1

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive FC detected inAnti-CD3/CD28 treated mouse splenocytes

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL405-98026 targets TIGIT in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 T cell immunoreceptor with Ig and ITIM domains
别名 Vstm3, 240242G1
计算分子量26kDa
GenBank蛋白编号NP_001139797.1
基因名称 Tigit
Gene ID (NCBI) 100043314
RRIDAB_3672411
偶联类型 CoraLite® Plus 405 Fluorescent Dye
最大激发/发射波长399 nm / 422 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDA0A0B4J1G6
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).

实验方案

Product Specific Protocols
FC protocol for CL Plus 405 TIGIT antibody CL405-98026Download protocol
Standard Protocols
Click here to view our Standard Protocols
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