TIMP-2 Polyclonal antibody

TIMP-2 Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

IHC,ELISA and More (1)

Conjugate

Unconjugated

Cat No : 17353-1-AP

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Synonyms

CSC 21K, Metalloproteinase inhibitor 2, TIMP 2, TIMP2, TIMP-2



经过测试的应用

Positive IHC detected inhuman kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

产品信息

17353-1-AP targets TIMP-2 in IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IHC,ELISA
Cited Applications IF, IHC
Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat, bovine
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TIMP-2 fusion protein Ag10051
Full Name TIMP metallopeptidase inhibitor 2
Synonyms CSC 21K, Metalloproteinase inhibitor 2, TIMP 2, TIMP2, TIMP-2
Calculated molecular weight 220 aa, 24 kDa
GenBank accession numberBC052605
Gene symbol TIMP2
UniprotP16035
Gene ID (NCBI) 7077
RRIDAB_2287495
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The TIMPs are natural highly specific endogenous inhibitors of MMPs. Human TIMP family consists of four 21-28 kDa proteins known as TIMP1, TIMP2, TIMP3, and TIMP4 encoded by four paralogous genes.TIMPs are vital to the maintenance of ECM homeostasis primarily through their MMP inhibitory functions. TIMP2, a member of the TIMP family, regulates the proteolytic activity of all MMPs and is involved in cell differentiation, growth, migration, angiogenesis, and apoptosis. Urinary TIMP2 has been recently recognized as an early biomarker to predict Acute kidney injury (AKI) in critically ill patients.

实验方案

Product Specific Protocols
IHC protocol for TIMP-2 antibody 17353-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Cell Death Dis

Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia.

Authors - Yuhua Ou
humanWB

Biomed Res Int

Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.

Authors - Xiaoxiao He
ratWB

Acta Biochim Biophys Sin (Shanghai)

Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.

Authors - Yaling Li
humanWB

Biochem Biophys Res Commun

Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A.

Authors - Xiaofeng Xue
humanWB

Biochem Biophys Res Commun

Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families.

Authors - Xiao-Xiao He
humanWB

Pathol Res Pract

Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway.

Authors - Haoran Li