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验证数据展示

  • FC experiment of human monocyte-derived immature dendritic cells using 98016-2-RR (same clone as 98016-2-PBS)

    FC experiment of human monocyte-derived immature dendritic cells using 98016-2-RR (same clone as 98016-2-PBS)

    1x10^6 human monocyte-derived immature dendritic cells were intracellularly stained with 0.25 ug Anti-Human TLR3/CD283 Rabbit Recombinant Antibody (98016-2-RR, Clone: 230445G9) or 0.25 ug Isotype Control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD11c. Cells were incubated with FC Receptor Block prior to fixing and staining. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98016-2-PBS in a different storage buffer formulation.

  • FC experiment of human monocyte-derived immature dendritic cells using 98016-2-RR (same clone as 98016-2-PBS)

    FC experiment of human monocyte-derived immature dendritic cells using 98016-2-RR (same clone as 98016-2-PBS)

    1x10^6 human monocyte-derived immature dendritic cells were intracellularly stained with 0.25 ug Anti-Human TLR3/CD283 Rabbit Recombinant Antibody (98016-2-RR, Clone: 230445G9) (red) or 0.25 ug Isotype Control (blue) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD11c. Cells were incubated with FC Receptor Block prior to fixing and staining. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98016-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98016-2-RR

    Affinity and Kinetic Characterization of 98016-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98016-2-RR against Human TLR3/CD283 were performed. The affinity constant is below 1 pM.

Anti-Human TLR3/CD283 Rabbit Recombinant Antibody, PBS Only

TLR3/CD283 Recombinant Antibody for FC (Intra)
Cat No. 98016-2-PBS

产品说明书

CloneNo. 230445G9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

TLR3, Toll-like receptor 3, toll like receptor 3, CD283, 230445G9

缓冲液配方:  PBS Only
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98016-2-PBS targets TLR3/CD283 in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 TLR3/CD283 fusion protein Ag34044 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 toll-like receptor 3
别名 TLR3, Toll-like receptor 3, toll like receptor 3, CD283, 230445G9
计算分子量 904 aa, 104 kDa
GenBank蛋白编号BC094737
基因名称 TLR3
Gene ID (NCBI) 7098
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDO15455
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TLR3 belongs to the Toll-like receptor family which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR3 is a nucleotide-sensing TLR that is activated by double-stranded RNA. Upon recognition of dsRNA, TLR3 transmits signals via the adaptor protein TICAM-1/TRIF, leading to the induction of type I IFN, cytokine/chemokine production, and dendritic cell (DC) maturation (PMID: 18262679).