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验证数据展示

  • WB analysis using 30301-1-AP

    WB analysis using 30301-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 30301-1-AP (TMEM106B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • WB analysis of HeLa using 30301-1-AP

    WB analysis of HeLa using 30301-1-AP

    WB result of TMEM106B antibody (30301-1-AP; 1:600; room temperature for 1.5 hours) with negative control and TMEM106B knockout HeLa cells.

  • Featured Product
  • KD/KO验证

TMEM106B (122-140aa) Polyclonal antibody

TMEM106B (122-140aa) Polyclonal Antibody for WB, ELISA
Cat No. 30301-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

Human

应用

WB, ELISA

别名

FLJ11273, TMEM106B, transmembrane protein 106B

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inA549 cells, HeLa cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

30301-1-AP targets TMEM106B (122-140aa) in WB, ELISA applications and shows reactivity with Human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 Human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transmembrane protein 106B
别名 FLJ11273, TMEM106B, transmembrane protein 106B
计算分子量 31 kDa
观测分子量45 kDa
GenBank蛋白编号BC033901
基因名称 TMEM106B
Gene ID (NCBI) 54664
RRIDAB_3086291
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NUM4
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. TMEM106B can be showed as 31-55 kDa and 70-90 kDa (Glycosylated or Dimer) form in western blot test. (PMID: 27543298, 22895706, PMID: 23136129).

实验方案

Product Specific Protocols
WB protocol for TMEM106B (122-140aa) antibody 30301-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols