TMPRSS2 Recombinant antibody, PBS Only

TMPRSS2 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 80152-1-PBS

产品说明书

CloneNo. 7I5

宿主/亚型

Rabbit / IgG

种属反应性

Human

应用

WB, Indirect ELISA

FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

80152-1-PBS targets TMPRSS2 in WB, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human
免疫原 TMPRSS2 fusion protein Ag5824 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transmembrane protease, serine 2
别名 FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2
计算分子量 54 kDa
观测分子量55 kDa
GenBank蛋白编号BC051839
基因名称 TMPRSS2
Gene ID (NCBI) 7113
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO15393
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumor metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses (PMID: 23468491, 30626688). SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor (PMID: 32142651, 30626688 ). Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells (PMID: 32142651). The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved into some chains with MW 54 kDa, 31 kDa and 26 kDa (PMID: 25734995, 20382709, 26018085).

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