TMPRSS6 Polyclonal antibody

TMPRSS6 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA and More (1)

Conjugate

Unconjugated

Cat no : 12950-1-AP

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Synonyms

IRIDA, Matriptase 2, TMPRSS6



经过测试的应用

Positive WB detected inHEK-293 cells, HepG2 cells, MCF-7 cells, mouse liver tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

12950-1-AP targets TMPRSS6 in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Cited ApplicationsWB, IF
Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Immunogen TMPRSS6 fusion protein Ag4076 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name transmembrane protease, serine 6
Synonyms IRIDA, Matriptase 2, TMPRSS6
Calculated Molecular Weight 89 kDa
Observed Molecular Weight 52 kDa
GenBank Accession NumberBC039082
Gene Symbol TMPRSS6
Gene ID (NCBI) 164656
RRIDAB_2877896
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8IU80
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.

实验方案

Product Specific Protocols
WB protocol for TMPRSS6 antibody 12950-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

Haematologica

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia.

Authors - Jing Liu
human,mouseWB,IF

Cell Death Dis

Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth

Authors - Yong Zuo
  • KD Validated