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TNC/Tenascin-C Monoclonal antibody, PBS Only

TNC/Tenascin-C Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F7G8

Cat no : 67710-1-PBS

Print datasheet

Synonyms

Cytotactin, GMEM, GP 150 225, Hexabrachion, HXB, JI, Myotendinous antigen, Neuronectin, Tenascin, tenascin C, TN, TN C, TNC

验证数据展示

  • WB analysis using 67710-1-Ig (same clone as 67710-1-PBS)

    WB analysis using 67710-1-Ig (same clone as 67710-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67710-1-Ig (TNC/Tenascin-C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67710-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 67710-1-Ig (same clone as 67710-1-PBS)

    IHC staining of human breast cancer using 67710-1-Ig (same clone as 67710-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67710-1-Ig (TNC/Tenascin-C antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67710-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TNC/Tenascin-C antibody included
  • IHC staining of human breast cancer using 67710-1-Ig (same clone as 67710-1-PBS)

    IHC staining of human breast cancer using 67710-1-Ig (same clone as 67710-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67710-1-Ig (TNC/Tenascin-C antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67710-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TNC/Tenascin-C antibody included
  • IF Staining of rat brain using 67710-1-Ig (same clone as 67710-1-PBS)

    IF Staining of rat brain using 67710-1-Ig (same clone as 67710-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded rat brain tissue using TNC/Tenascin-C antibody (67710-1-Ig, Clone: 1F7G8 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67710-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy TNC/Tenascin-C Ready-To-Use IHC Kit. TNC/Tenascin-C primary antibody included.

产品信息

67710-1-PBS targets TNC/Tenascin-C in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human, Mouse, Rat
Immunogen TNC/Tenascin-C fusion protein Ag21412 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name tenascin C
Synonyms Cytotactin, GMEM, GP 150 225, Hexabrachion, HXB, JI, Myotendinous antigen, Neuronectin, Tenascin, tenascin C, TN, TN C, TNC
Calculated Molecular Weight 2201 aa, 241 kDa
Observed Molecular Weight260 kDa
GenBank Accession NumberBC151843
Gene Symbol Tenascin C
Gene ID (NCBI) 3371
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP24821
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein of the tenascin family (PMID: 21818551). It is a multimodular protein containing multiple epidermal growth factor (EGF)-like repeats and fibronectin type III (FN III) domains (PMID: 1719530). Tenascin-C is highly expressed during embryonic development, particularly in the developing central nervous system, around motile cells and at epithelial-mesenchymal interaction sites (PMID: 25738825). In adult tissues, the expression and the distribution of TNC are typically limited under normal physiological conditions. It is upregulated during injury, inflammation, regeneration, and cancer (PMID: 7694605; 25120494). Tenascin-C is a diverse protein that can produce different functions including regulating cell adhesion, migration and proliferation.