TNFR2/CD120b Recombinant antibody, PBS Only (Detector)

TNFR2/CD120b Uni-rAbTM Recombinant Antibody for Cytometric bead array, Indirect ELISA
Cat No. 98010-1-PBS

产品说明书

CloneNo. 230328B3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

Cytometric bead array, Indirect ELISA

TNFRSF1B, p80 TNF alpha receptor, p75TNFR, p75, Etanercept

缓冲液配方:  PBS Only
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy TNFR2/TNFRSF1B Ready-To-Use IHC Kit. TNFR2/TNFRSF1B primary antibody included.

产品信息

98010-1-PBS targets TNFR2/CD120b as part of a matched antibody pair:

MP00777-1: 83101-2-PBS capture and 98010-1-PBS detection (validated in Cytometric bead array)

MP00777-2: 83101-3-PBS capture and 98010-1-PBS detection (validated in Cytometric bead array)

MP00777-3: 83101-4-PBS capture and 98010-1-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 1B
别名 TNFRSF1B, p80 TNF alpha receptor, p75TNFR, p75, Etanercept
计算分子量 48 kDa
GenBank蛋白编号BC052977
基因名称 TNFR2
Gene ID (NCBI) 7133
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP20333
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C. Stable for one year after shipment.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tumor necrosis factor-alpha (TNFA/TNFSF2) is a multifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNFA signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a, p55) and TNFR2 (TNFRSF1B, CD120b, p75). TNFR1 is widely expressed, whereas TNFR2 exhibits more restricted expression, being found on CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells (PMID: 20489699; 22374304). In contrast to TNFR1, TNFR2 does not have a death domain. TNFR2 only signals for antiapoptotic reactions. However, recent evidence indicates that TNFR2 also signals to induce TRAF2 degradation (PMID: 22374304). Various defects in the TNFR2 pathway, due to polymorphisms in the TNFR2 gene, upregulated expression of TNFR2 and TNFR2 shedding, have been implicated in the pathology of several autoimmune disorders (PMID: 20489699).

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