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BCMA/TNFRSF17 Polyclonal antibody, PBS Only

BCMA/TNFRSF17 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 27724-1-PBS

Print datasheet

Synonyms

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

验证数据展示

  • IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

    IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • WB analysis of Daudi using 27724-1-AP (same clone as 27724-1-PBS)

    WB analysis of Daudi using 27724-1-AP (same clone as 27724-1-PBS)

    Daudi and Ramos cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

产品信息

27724-1-PBS targets BCMA/TNFRSF17 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen BCMA/TNFRSF17 fusion protein Ag27049 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name tumor necrosis factor receptor superfamily, member 17
Synonyms TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein
Calculated Molecular Weight 184 aa, 20 kDa
Observed Molecular Weight 20 kDa
GenBank Accession NumberBC058291
Gene Symbol TNFRSF17
Gene ID (NCBI) 608
RRIDAB_2880954
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ02223
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).