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TREK1/KCNK2 Polyclonal antibody

TREK1/KCNK2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 26807-1-AP

Print datasheet

Synonyms

hTREK 1c, hTREK 1e, K2p2.1, KCNK2, TPKC1, TREK, TREK 1, TREK 1 K(+) channel subunit, TREK1

验证数据展示

  • WB analysis using 26807-1-AP

    WB analysis using 26807-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 26807-1-AP (TREK1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inLNCaP cells, SH-SY5Y cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

26807-1-AP targets TREK1/KCNK2 in WB, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen TREK1/KCNK2 fusion protein Ag25209 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name potassium channel, subfamily K, member 2
Synonyms hTREK 1c, hTREK 1e, K2p2.1, KCNK2, TPKC1, TREK, TREK 1, TREK 1 K(+) channel subunit, TREK1
Calculated Molecular Weight 411 aa, 46 kDa
Observed Molecular Weight40-50 kDa
GenBank Accession NumberBC101693
Gene Symbol TREK1
Gene ID (NCBI) 3776
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO95069
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The tandem of pore domains in a weak inward rectifying K+ channel (TWIK1, K2P1.1, or KCNK1) and TWIK-related K+channel 1 (TREK1, K2P 2.1, or KCNK2) are members of the two pore domain potassium (K2P) channel family, consisting of 15 channels that regulate the stabilization of resting membrane potential and cellular excitability by wielding background K+ leakage currents (PMID:12580339). TREK1/KCNK2 is sensitive to a wide range of physical and chemical cues. Its main role is to maintain the resting potential of the cell and whilst highly expressed in the nervous system, TREK1/KCNK2 is also expressed in the kidney, heart, lung and smooth muscle cells (PMID:31031627).

实验方案

Product Specific Protocols
WB protocol for TREK1/KCNK2 antibody 26807-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols