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  • KD/KO Validated

TREX1 Polyclonal antibody

TREX1 Polyclonal Antibody for WB, IF/ICC, IP, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IF/ICC, IP, ELISA and More (1)

Conjugate

Unconjugated

Cat no : 24876-1-AP

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Synonyms

DRN3, Deoxyribonuclease III, CRV, AGS5, 3'-5' exonuclease TREX1



经过测试的应用

Positive WB detected inHeLa cells, HepG2 cells
Positive IP detected inHeLa cells
Positive IF/ICC detected inRAW 264.7 cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

24876-1-AP targets TREX1 in WB, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IF/ICC, IP, ELISA Application Description
Cited ApplicationsWB, IF
Tested Reactivity human, mouse
Cited Reactivityhuman, bovine
Immunogen TREX1 fusion protein Ag18325 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name three prime repair exonuclease 1
Synonyms DRN3, Deoxyribonuclease III, CRV, AGS5, 3'-5' exonuclease TREX1
Calculated Molecular Weight 369 aa, 39 kDa
Observed Molecular Weight 32-39 kDa
GenBank Accession NumberBC023630
Gene Symbol TREX1
Gene ID (NCBI) 11277
RRIDAB_2879772
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NSU2
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TREX1 (three prime repair exonuclease 1), also known as trophoblast expressed 1, CRV, AGS1, AGS5, DRN3, HERNS or DNase III, is a member of the exonuclease superfamily and belongs to the TREX family. TREX1 may play a role in DNA repair. TREX1 is expressed in thymus, spleen, liver, brain, heart, small intestine and colon. Mutations or defects in the gene encoding TREX1 have been associated with a variety of diseases, including systemic lupus erythematosus, chilblain lupus (CHBL), Aicardi-Goutieres syndrome type 1 (AGS1) and type 5 (AGS5).

实验方案

Product Specific Protocols
WB protocol for TREX1 antibody 24876-1-APDownload protocol
IF protocol for TREX1 antibody 24876-1-APDownload protocol
IP protocol for TREX1 antibody 24876-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle

J Neuropathol Exp Neurol

Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation.

Authors - Rie Saito
humanWB

bioRxiv

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

Authors - Cason R King
  • KO Validated
humanIF,WB

Cell Host Microbe

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

Authors - Cason R King
humanWB

Cell Rep

Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition

Authors - Yan Li
bovineWB

Int J Mol Sci

Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells

Authors - Miaomiao Yang