验证数据展示
产品信息
67342-1-PBS targets TRIM2 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat, Pig samples.
经测试应用 | WB, IHC, IF-P, Indirect ELISA Application Description |
经测试反应性 | Human, Mouse, Rat, Pig |
免疫原 | TRIM2 fusion protein Ag14637 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | tripartite motif-containing 2 |
别名 | KIAA0517, RING finger protein 86, RNF86, TRIM2, tripartite motif containing 2 |
计算分子量 | 744 aa, 82 kDa |
观测分子量 | 70-85 kDa |
GenBank蛋白编号 | BC011052 |
基因名称 | TRIM2 |
Gene ID (NCBI) | 23321 |
RRID | AB_2882600 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q9C040 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tripartite motif-containing 2(TRIM2) is an E3 ubiquitin ligase which directs proteasome-mediated degradation of target proteins by the ubiquitination of NEFL and phosphorylation of BCL2L11. This protein contains an N-terminal RING domain, followed by a B-box-2 domain, a coiled-coil region, and 6 C-terminal NHL repeats. TRIM2 involves in the apoptotic response to ischemia via directing degradation of BIM protein, thus has a role in neuroprotection.