验证数据展示
产品信息
67241-1-PBS targets Thrombospondin 1 in WB, Indirect ELISA applications and shows reactivity with Human, rat, mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human, rat, mouse |
| 免疫原 | Thrombospondin 1 fusion protein Ag29129 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | thrombospondin 1 |
| 别名 | THBS, THBS 1, THBS1, thrombospondin 1, Thrombospondin-1, TSP, TSP 1, TSP1, TSP-1 |
| 计算分子量 | 129 kDa |
| 观测分子量 | 160 kDa |
| GenBank蛋白编号 | NM_003246 |
| 基因名称 | Thrombospondin 1 |
| Gene ID (NCBI) | 7057 |
| RRID | AB_2882520 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P07996 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Thrombospondin 1(TSP-1), an extracellular matrix protein, is the first identified natural angiogenesis inhibitor. A variety of normal cells, including endothelial cells, fibroblasts, adipocytes, smooth muscle cells, monocytes, macrophages, and transformed cells such as malignant glioma cells, secrete Thrombospondin 1. It regulates cellular phenotype during tissue genesis and repair. It acts as a molecular facilitator by bringing together cytokines, growth factors, matrix components, membrane receptors and extracellular proteases. Thrombospondin 1 binds to a wide variety of integrin and non-integrin cell surface receptors. It is also a major activator of transforming growth factor (TGFβ1). Secreted TSP1 is a glycoprotein with a molecular mass of 150-180 kDa.
