验证数据展示
产品信息
60272-1-PBS targets Thyroglobulin in IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IHC, IF-P, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Thyroglobulin fusion protein Ag18070 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | thyroglobulin |
| 别名 | TG, 4D3C5 |
| 计算分子量 | 2768 aa, 305 kDa |
| GenBank蛋白编号 | BC140933 |
| 基因名称 | Thyroglobulin |
| Gene ID (NCBI) | 7038 |
| RRID | AB_2881392 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P01266 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
