验证数据展示
产品信息
60272-1-PBS targets Thyroglobulin in IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.
| Tested Applications | IHC, IF-P, Indirect ELISA Application Description |
| Tested Reactivity | human |
| Immunogen | Thyroglobulin fusion protein Ag18070 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | thyroglobulin |
| Synonyms | TG, 4D3C5 |
| Calculated Molecular Weight | 2768 aa, 305 kDa |
| GenBank Accession Number | BC140933 |
| Gene Symbol | Thyroglobulin |
| Gene ID (NCBI) | 7038 |
| RRID | AB_2881392 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P01266 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
