验证数据展示
经过测试的应用
| Positive WB detected in | mouse retina tissue, mouse eye tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
21007-1-AP targets Thyroid Hormone Receptor beta in WB, IHC, IF, ELISA applications and shows reactivity with Mouse samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | Mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 | Thyroid Hormone Receptor beta fusion protein Ag15210 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) |
| 别名 | c erbA 2, c erbA beta, ERBA BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB, THRB1, THRB2, Thyroid Hormone Receptor beta |
| 计算分子量 | 476 aa, 54 kDa |
| 观测分子量 | 50 kDa |
| GenBank蛋白编号 | BC106929 |
| 基因名称 | Thyroid Hormone Receptor beta |
| Gene ID (NCBI) | 7068 |
| RRID | AB_3085632 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P10828 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Thyroid hormone receptor beta (THRB), also known as ERBA2, NR1A2, and THR1, belongs to the nuclear hormone receptor family and NR1 subfamily. THRB is a nuclear hormone receptor that can act as a repressor or activator of transcription. Moreover, THRB is also a high-affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. THRB is the most abundant THR isoform in the liver but is also expressed in other tissues and mediates the effects of THs on hepatic carbohydrate and lipid metabolism (PMID: 34884910).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for Thyroid Hormone Receptor beta antibody 21007-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Theranostics Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease
| ||
Biomark Insights The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases |