验证数据展示
产品信息
27867-1-PBS targets Titin in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | IHC, IF/ICC, IF-P, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | Titin fusion protein Ag27496 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | titin |
别名 | TTN |
计算分子量 | 3816 kDa |
GenBank蛋白编号 | NM_001256850 |
基因名称 | Titin |
Gene ID (NCBI) | 7273 |
RRID | AB_2880998 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q8WZ42 |
储存缓冲液 | PBS Only |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Titin, or connectin, is a giant muscle protein expressed in the cardiac and skeletal muscles that spans half of the sarcomere from Z line to M line. It plays a key role in muscle contraction and relaxation, maintaining the structural integrity of the myotome(PMID: 11846417). Mutations in Titin are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma(PMID: 15802564).