Anti-Mouse TNFR2/CD120b Rabbit Recombinant Antibody, PBS Only

TNFR2/CD120b Uni-rAbTM Recombinant Antibody for FC
Cat No. 98021-1-PBS

Print datasheet

CloneNo. 240200D4

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

CD120b, TNFR2, Tnfrsf1b, 240200D4, TNF R2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -


产品信息

98021-1-PBS targets TNFR2/CD120b in FC applications and shows reactivity with mouse samples.

Tested Applications FC Application Description
Tested Reactivity mouse
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name tumor necrosis factor receptor superfamily, member 1b
Synonyms CD120b, TNFR2, Tnfrsf1b, 240200D4, TNF R2
Calculated Molecular Weight50KD
GenBank Accession NumberNM_011610.3
Gene Symbol Tnfrsf1b
Gene ID (NCBI) 21938
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ545P4
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tumor necrosis factor-alpha (TNFA/TNFSF2) is a multifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNFA signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a, p55) and TNFR2 (TNFRSF1B, CD120b, p75). TNFR1 is widely expressed, whereas TNFR2 exhibits more restricted expression, being found on CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells (PMID: 20489699; 22374304). In contrast to TNFR1, TNFR2 does not have a death domain. TNFR2 only signals for antiapoptotic reactions. However, recent evidence indicates that TNFR2 also signals to induce TRAF2 degradation (PMID: 22374304). Various defects in the TNFR2 pathway, due to polymorphisms in the TNFR2 gene, upregulated expression of TNFR2 and TNFR2 shedding, have been implicated in the pathology of several autoimmune disorders (PMID: 20489699).

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