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UCKL1 Polyclonal antibody, PBS Only

UCKL1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28762-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 28762-1-AP (same clone as 28762-1-PBS)

    WB analysis using 28762-1-AP (same clone as 28762-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28762-1-AP (UCKL1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28762-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 28762-1-AP (same clone as 28762-1-PBS)

    IHC staining of human liver cancer using 28762-1-AP (same clone as 28762-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 28762-1-AP (UCKL1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28762-1-PBS in a different storage buffer formulation.

产品信息

28762-1-PBS targets UCKL1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen UCKL1 fusion protein Ag30535 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name uridine-cytidine kinase 1-like 1
Synonyms
Calculated Molecular Weight 419 aa, 46 kDa
Observed Molecular Weight61 kDa
GenBank Accession NumberBC033078
Gene Symbol UCKL1
Gene ID (NCBI) 54963
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NWZ5
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Uridine cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein over-expressed in many tumor cells, especially in highly malignant, aggressive tumors. Sequence analysis indicates that UCKL-1 has homology to uridine kinases, enzymes that play a role in DNA and RNA synthesis and that are often up-regulated in tumor cells. Previous studies have shown that UCKL-1 is a substrate for natural killer lytic-associated molecule (NKLAM), an E3 ubiquitin ligase found in NK cell cytolytic granules. Ubiquitination of UCKL-1 by NKLAM leads to its degradation. Increased expression of NKLAM enhances NK-mediated tumoricidal activity. (PMID: 32083188)