验证数据展示
发表文章中的应用
| WB | See 2 publications below |
| IHC | See 2 publications below |
产品信息
13127-2-AP targets UGT1A6 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, rat |
| 免疫原 | UGT1A6 fusion protein Ag3792 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| 别名 | GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1 6, UGT 1F, UGT1, UGT1 06, UGT1*6, UGT1.6, UGT1A6, UGT1A6S, UGT1F |
| 计算分子量 | 532 aa, 61 kDa |
| GenBank蛋白编号 | BC019861 |
| 基因名称 | UGT1A6 |
| Gene ID (NCBI) | 54578 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P19224 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
UGT1A6 belongs to the UDP-glycosyltransferase family functioning to catalyze the transfer of glycosyl groups to lipophilic substrates, which play a key role in the inactivation and elimination of many endogenous and exogenous compounds. UGT1A6 is responsible for the glucuronida-tion of many xenobiotics and several drugs, like paracetamol, valproate,and deferiprone. It also metabolizes several important endogenous substrates such as serotonin. Polymorphisms exists in UGT1A6 gene. Studies have demonstrated very widespread variability in the expression of UGT1A6 in liver.
发表文章
| Species | Application | Title |
|---|---|---|
Cancer Chemother Pharmacol Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells. | ||
Neurotherapeutics Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications. |