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ULK1-IN-2

ULK1-IN-2 是一种有效的 ULK1 抑制剂，具有潜在的抗癌活性，可诱导细胞凋亡同时阻断自噬。ULK1-IN-2 对癌细胞具有较高的细胞毒作用，对 A549 细胞的 IC50 值为 1.94 μM。ULK1-IN-2 可用于研究非小细胞肺癌。

CAS号

2497409-01-3

分子式

C19H16BrFN4O6

主要靶点

Autophagy|Apoptosis

仅限科研使用

Cat No : CM08937

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Synonyms

验证数据展示

  • CAS No.: 2497409-01-3

    ULK1-IN-2
    CAS#: 2497409-01-3

产品信息

ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer.

CAS号 2497409-01-3
分子式 C19H16BrFN4O6
主要靶点 Autophagy|Apoptosis
主要通路 自噬|凋亡
分子量 495.26
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

体外活性

ULK1-IN-2 (compound 3s) (10 μM; 24 h) exhibits potent anti-proliferative activity against A549, U937, HL60, MDA-MB-468, and MCF-7 cells. In A549 cells, ULK1-IN-2 hinders autophagy by inhibiting ULK1. Furthermore, ULK1-IN-2 induces apoptosis through the mitochondrial pathways in A549 cells in a dose-dependent manner and inhibits ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, leading to Bcl-2 expression significantly decrease and an increase in Bax and the active form of Caspase-3 expression.[1]

溶解度

DMSO:30 mg/mL (60.57 mM),Sonification is recommended.

参考文献

1.Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.

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