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  • Featured Product
  • KD/KO Validated

VDR Monoclonal antibody, PBS Only

VDR Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, mouse, rat

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A9C1

Cat No : 67192-1-PBS

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Synonyms

NR1I1, VDR, Vitamin D3 receptor

验证数据展示

  • WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

    WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

产品信息

67192-1-PBS targets VDR in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen VDR fusion protein Ag28188 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name vitamin D (1,25- dihydroxyvitamin D3) receptor
Synonyms NR1I1, VDR, Vitamin D3 receptor
Calculated Molecular Weight 48 kDa
Observed Molecular Weight 48-55 kDa
GenBank Accession NumberBC060832
Gene Symbol VDR
Gene ID (NCBI) 7421
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP11473
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. The VDR exists two isoform with the MV 48 kDa and 54 kDa.