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VEGFR2 Monoclonal antibody, PBS Only

VEGFR2 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1G2A8

Cat No : 67407-1-PBS

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Synonyms

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2

验证数据展示

  • WB analysis of human placenta using 67407-1-Ig (same clone as 67407-1-PBS)

    WB analysis of human placenta using 67407-1-Ig (same clone as 67407-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 67407-1-Ig (VEGFR2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67407-1-PBS in a different storage buffer formulation.

产品信息

67407-1-PBS targets VEGFR2 in WB, ELISA applications and shows reactivity with Human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human
Immunogen VEGFR2 fusion protein Ag24589 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name kinase insert domain receptor (a type III receptor tyrosine kinase)
Synonyms CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2
Calculated Molecular Weight 1356 aa, 152 kDa
Observed Molecular Weight 230 kDa
GenBank Accession NumberBC131822
Gene Symbol KDR
Gene ID (NCBI) 3791
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP35968
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

背景介绍

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.