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CoraLite® Plus 488-conjugated VEGFR2/KDR Monoclonal antibody

VEGFR2/KDR Monoclonal Antibody for

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1G2A8

Cat No : CL488-67407

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Synonyms

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2

验证数据展示

For other applications, we recommend the unconjugated version of this antibody, 67407-1-Ig

产品信息

CL488-67407 targets VEGFR2/KDR in applications and shows reactivity with Human samples.

Tested Applications Application Description
Tested Reactivity Human
Immunogen VEGFR2/KDR fusion protein Ag24589 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name kinase insert domain receptor (a type III receptor tyrosine kinase)
Synonyms CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2
Calculated Molecular Weight 1356 aa, 152 kDa
Observed Molecular Weight 230 kDa
GenBank Accession NumberBC131822
Gene Symbol KDR
Gene ID (NCBI) 3791
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP35968
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.