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VU-29

VU-29 是代谢型谷氨酸 5(mGlu5)受体的正变构调节剂，对 rmGluR5 的 EC50为 9 nM，Ki 为 244 nM。相对于其他亚型，它对 mGluR5 具有选择性，对 rmGluR1/rmGluR2和 hmGluR4的 EC50分别为557 nM/1.5 μM 和 154 nM。

CAS号

890764-36-0

分子式

C22H16N4O3

主要靶点

GluR

仅限科研使用

Cat No : CM05104

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Synonyms

VU 29

验证数据展示

  • CAS No.: 890764-36-0

    VU-29
    CAS#: 890764-36-0

产品信息

VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).

CAS号 890764-36-0
分子式 C22H16N4O3
主要靶点 GluR
主要通路 神经科学
分子量 384.39
纯度 99.47%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 VU 29

靶点活性

rat mGluR2:1.5 μM (EC50)|rat mGluR5:224 nM (Ki)|rat mGluR5:9 nM (EC50)|rat mGluR1:557 nM (EC50)|hmGluR4:154 nM (EC50)

溶解度

DMSO:25 mg/mL (65.04 mM)

参考文献

1.Chen Y , Nong Y , Goudet C , et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.[J]. Molecular Pharmacology, 2007, 71(5):1389-1398.

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