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Vps34-IN-1

Vps34-IN-1 (VPS34-IN1) 是一种有效且高度选择性的 Vps34 抑制剂，可调节自噬，来自从专利WO2012085815A1，化合物实例16a，IC50为4nM。

CAS号

1383716-33-3

分子式

C21H24ClN7O

主要靶点

PI3K|Autophagy

仅限科研使用

Cat No : CM05975

Print datasheet

Synonyms

VPS34-IN1

验证数据展示

  • CAS No.: 1383716-33-3

    Vps34-IN-1
    CAS#: 1383716-33-3

产品信息

Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

CAS号 1383716-33-3
分子式 C21H24ClN7O
主要靶点 PI3K|Autophagy
主要通路 自噬|PI3K/Akt/mTOR信号通路
分子量 425.91
纯度 97.04%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 VPS34-IN1

靶点活性

Vps34:25 nM

体外活性

Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1].

溶解度

DMSO:79 mg/mL (185.5 mM),Ethanol:79 mg/mL (185.5 mM),H2O:<1 mg/mL

参考文献

1.Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27.
2.Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026.
3.Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020

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