CRM1 Polyclonal antibody

CRM1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA and More (1)

Conjugate

Unconjugated

Cat no : 12915-1-AP

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Synonyms

CRM1, Exp1, Exportin 1, XPO1



Planning an IHC experiment? We recommend our IHCeasy CRM1 Ready-To-Use IHC Kit. CRM1 primary antibody included.

发表文章中的应用

WBSee 1 publications below

产品信息

12915-1-AP targets CRM1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications ELISA Application Description
Cited ApplicationsWB
Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Immunogen CRM1 fusion protein Ag3488 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name exportin 1 (CRM1 homolog, yeast)
Synonyms CRM1, Exp1, Exportin 1, XPO1
Calculated Molecular Weight 1071 aa, 123 kDa
Observed Molecular Weight 100-110 kDa
GenBank Accession NumberBC032847
Gene Symbol CRM1
Gene ID (NCBI) 7514
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO14980
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).

发表文章

SpeciesApplicationTitle
humanWB

Toxicology

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Authors - Chuanyang Su