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YHO-13177

YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。

CAS号

912287-56-0

分子式

C20H22N2O3S

主要靶点

BCRP

仅限科研使用

Cat No : CM03147

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Synonyms

YHO13177|YHO 13177

验证数据展示

  • CAS No.: 912287-56-0

    YHO-13177
    CAS#: 912287-56-0

产品信息

YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.

CAS号 912287-56-0
分子式 C20H22N2O3S
主要靶点 BCRP
主要通路 离子通道
分子量 370.47
纯度 98.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 YHO13177|YHO 13177

溶解度

DMSO:45 mg/mL (121.47 mM)

参考文献

1.Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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