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YHO-13351 free base

YHO-13351 free base 是 YHO-13177 的水溶性前药，YHO-13177 是 BCRP 的抑制剂。

CAS号

912288-64-3

分子式

C26H33N3O4S

主要靶点

BCRP

仅限科研使用

Cat No : CM07520

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Synonyms

验证数据展示

  • CAS No.: 912288-64-3

    YHO-13351 free base
    CAS#: 912288-64-3

产品信息

YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .

CAS号 912288-64-3
分子式 C26H33N3O4S
主要靶点 BCRP
主要通路 离子通道
分子量 483.62
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models[1].

溶解度

DMSO:90mg/mL (186.1mM),Sonification is recommended.

参考文献

1.Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.
2.Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86.

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