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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 67911-1-Ig (same clone as 67911-1-PBS)

    WB analysis using 67911-1-Ig (same clone as 67911-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67911-1-Ig (YTHDC1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with Lamin B1 Monoclonal antibody (66095-1-Ig) as loading control. This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of human cervical cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human cervical cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included

YTHDC1 Monoclonal antibody, PBS Only

YTHDC1 Monoclonal Antibody for WB, IHC, ELISA
Cat No. 67911-1-PBS

产品说明书

CloneNo. 1F5G11

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse

应用

WB, IHC, ELISA

别名

KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy YTHDC1 Ready-To-Use IHC Kit. YTHDC1 primary antibody included.

产品信息

67911-1-PBS targets YTHDC1 in WB, IHC, ELISA applications and shows reactivity with Human, mouse samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 Human, mouse
免疫原 YTHDC1 fusion protein Ag6289 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 YTH domain containing 1
别名 KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1
计算分子量 85 kDa
观测分子量~100 kDa
GenBank蛋白编号BC053863
基因名称 YTHDC1
Gene ID (NCBI) 91746
RRIDAB_2918666
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ96MU7
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

YTHDC1, containing 1 YTH domain, is one of the m6A-binding proteins that can recognize and bind to the m6A methylation site and plays a specific role in gene expression. YTHDC1 is constitutively enriched in the nucleus. It regulates mRNA splicing by bridging the interactions between the trans- and cis-regulatory elements to bind targeted mRNAs. YTHDC1 mediates the export of m6A modified mRNA from the nucleus to the cytoplasm by interacting with SRSF3, which is an essential factor driving the tumorigenic process in various types of cancers including breast cancer, colon cancer, ovarian cancer, osteosarcoma, and glioblastoma (32368386).