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YTHDC1 Monoclonal antibody, PBS Only

YTHDC1 Monoclonal Antibody for WB,IHC,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

WB,IHC,ELISA

Conjugate

Unconjugated

CloneNo.

1F5G11

Cat No : 67911-1-PBS

Print datasheet

Synonyms

KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1

验证数据展示

  • WB analysis using 67911-1-Ig (same clone as 67911-1-PBS)

    WB analysis using 67911-1-Ig (same clone as 67911-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67911-1-Ig (YTHDC1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with Lamin B1 Monoclonal antibody (66095-1-Ig) as loading control. This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human breast cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of human cervical cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of human cervical cancer using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
  • IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    IHC staining of mouse testis using 67911-1-Ig (same clone as 67911-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 67911-1-Ig (YTHDC1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67911-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with YTHDC1 antibody included
Planning an IHC experiment? We recommend our IHCeasy YTHDC1 Ready-To-Use IHC Kit. YTHDC1 primary antibody included.

产品信息

67911-1-PBS targets YTHDC1 in WB, IHC, ELISA applications and shows reactivity with Human, mouse samples.

Tested Applications WB,IHC,ELISA Application Description
Tested Reactivity Human, mouse
Immunogen YTHDC1 fusion protein Ag6289 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name YTH domain containing 1
Synonyms KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1
Calculated Molecular Weight 85 kDa
Observed Molecular Weight~100 kDa
GenBank Accession NumberBC053863
Gene Symbol YTHDC1
Gene ID (NCBI) 91746
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ96MU7
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

背景介绍

YTHDC1, containing 1 YTH domain, is one of the m6A-binding proteins that can recognize and bind to the m6A methylation site and plays a specific role in gene expression. YTHDC1 is constitutively enriched in the nucleus. It regulates mRNA splicing by bridging the interactions between the trans- and cis-regulatory elements to bind targeted mRNAs. YTHDC1 mediates the export of m6A modified mRNA from the nucleus to the cytoplasm by interacting with SRSF3, which is an essential factor driving the tumorigenic process in various types of cancers including breast cancer, colon cancer, ovarian cancer, osteosarcoma, and glioblastoma (32368386).